The invention discloses a design method for a vehicle body front-end structure with vehicle front surface 25% overlapping ratio collision, and aims to solve the problems of design blindness in an existing optimization design process for vehicle body front-end members with vehicle front surface 25% overlapping ratio collision, and repeated modeling and long calculation time during adoption of a CAE technical means in the optimization design process. The design method for the vehicle body front-end structure with the vehicle front surface 25% overlapping ratio collision comprises the steps of 1, building an equivalent simplified model of a vehicle: 1) extracting a stiffness characteristic and an inertia characteristic; 2) parameterizing the extracted stiffness characteristic and inertia characteristic; 3) clearly determining a simulation mode of an equivalent simplified model of each member of the vehicle body front-end structure; 4) simplifying a front longitudinal beam, a front fingerboard and an auxiliary frame; 5) processing other parts of a vehicle body; and 6) verifying the equivalent simplified model of the vehicle; 2, obtaining an anti-collision design objective of the vehicle body front-end structure; 3, designing the front longitudinal beam, the front fingerboard and the auxiliary frame; and 4, performing simulation verification on front surface collision resistance of the vehicle body front-end structure after optimization design.