The invention discloses a humidity-regulating spacer used for food and drug packages and a manufacturing method of the spacer. The humidity-regulating spacer comprises a breathable film, a humidity-regulating mixture and a spacer body, wherein the breathable film is provided with an opening, the humidity-regulating mixture is arranged in the breathable film provided with the opening, and the spacer body is arranged at the opening of the breathable film provided with the opening. The manufacturing method of the humidity-regulating spacer comprises the steps of technological preparation of an automatic production line, feeding, injection of the humidity-regulating mixture into a concave cavity of the breathable film provided with the opening, welding of the spacer body to the opening of the breathable film provided with the opening in a covering mode, low-temperature drying, checking, vacuumizing of an aluminum foil bag, and packaging. According to the humidity-regulating spacer used for food and drug packages and the manufacturing method of the spacer, the humidity-regulating mixture is packaged in the concave cavity of the microporous film, and oxygen molecules and water molecules can penetrate through the microporous film to be adsorbed by the mixture and are accumulated in the mixture, so that air in bottles and cans used for storing food and drugs is extremely dry, the oxygen content is extremely low, and odor is sufficiently adsorbed; and it is ensured that food and drugs can be stored in the bottles and cans for a long time without going bad, and the situation that an original spacer only has a sealing function is changed.