利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN106749558A 广谱抑制HIV的脂肽、其衍生物、其药物组合物及其用途 有权

广谱抑制HIV的脂肽、其衍生物、其药物组合物及其用途
摘要：
本发明公开了广谱抑制HIV的脂肽、其衍生物、其药物组合物及其用途。该脂肽为下述a)或b)：a)所述脂肽包括具有抗病毒活性的多肽，与所述多肽的羧基末端相连的连接臂，与所述连接臂相连的氨基酸X残基和与所述氨基酸X残基相连的亲脂性化合物；b)所述脂肽包括具有抗病毒活性的多肽，与所述多肽的羧基末端相连的亲脂性化合物；所述病毒为下述v1‑v7中的任一：v1、HIV‑1、HIV‑2和SIV；v2、HIV‑1和HIV‑2；v3、HIV‑1和SIV；v4、HIV‑2和SIV；v5、HIV‑1；v6、HIV‑2；v7、SIV；所述氨基酸X为K或C或S或T或Y。本发明可以用于HIV感染的治疗和/或预防。
摘要（英）：

The invention discloses a lipopeptid for restraining HIV with a broad spectrum, derivatives, a drug compound and an application thereof. The lipopeptid is a) or b) as follows: a) the lipopeptid comprises a polypeptide, a connecting arm, an amino acid X residual group and a lipotropy compound, wherein the polypeptide has an antiviral activity, the connecting arm is connected with the carboxyl terminal of the polypeptide, the amino acid X residual group is connected with the connecting arm and the lipotropy compound is connected with the amino acid X residual group; b) the lipopeptid comprises the polypeptide and the lipotropy compound, wherein the polypeptide has the antiviral activity and the lipotropy compound is connected with the carboxyl terminal of the polypeptide; the virus is any one of v1 to v7 as follows: v1, HIV-1, HIV-2 and SIV; v2, HIV-1 and HIV-2; v3, HIV-1 and SIV; v4, HIV-2 and SIV; v5 and HIV-1; v6 and HIV-2; v7 and SIV; the amino acid X is K, C, S, T or Y. The lipopeptid can be used for treating and/or preventing HIV infection.

公开/授权文献
0/0