The invention relates to a radiation-resistant high-polymer material as well as a preparation method and application thereof, and solves the technical problems that after the high-polymer material is irradiated by high-energy rays or electron beams, the change in color is still more obvious, and the mechanical property is more greatly reduced. The radiation-resistant high-polymer material is prepared from the following components in parts by weight: 100 parts of base resin with a weight-average molecular weight of 100,000-200,000, 2-7 parts of inorganic nano-particles, 3-7 parts of a primary antioxidant, 4-5 parts of an auxiliary antioxidant, 3-7 parts of a light stabilizer and 3-6 parts of a ultraviolet absorbent. The invention simultaneously discloses the preparation method and the application of the radiation-resistant high-polymer material. The preparation method provided by the invention can be used in the field of the preparation of radiation-resistant high-polymer materials.