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发明公开
CN106754922A 调控自身增殖的轮状病毒编码的小RNA分子 无效 - 驳回

调控自身增殖的轮状病毒编码的小RNA分子
摘要：
本发明涉及生物医药领域，尤其是一种由病毒自身编码的小RNA分子。本发明公开了一种调控自身增殖的轮状病毒编码小RNA分子，命名为 RV‑vsRNA1755，其特征在于其核苷酸序列为：5‘ATTCAGGATCCTGGAATGGCG3’；RV‑VSRNA1755分子的序列位于NSP4基因的114aa‑115aa区域，即卷曲螺旋区域（coiled‑coil region）。轮状病毒编码的小RNA研究能够进一步了解轮状病毒与宿主细胞之间相互调控关系，为寻找特异性针对轮状病毒感染的药物提供可能途径，为将来以RV‑VSRNA1755分子为轮状病毒治疗靶点的药物筛选提供了理论依据。
摘要（英）：

The invention relates to the field of biological medicines, and in particular to a rotavirus-encoded small RNA molecule regulating self proliferation. The invention discloses the rotavirus-encoded small RNA molecule regulating self proliferation, wherein the molecule is named RV-vsRNA1775. The small RNA molecule is characterized in that the nucleotide sequence of the small RNA molecule is 5'ATTCAGGATCCTGGAATGGCG3'; the sequence of the RV-VSRNA1775 molecule is located in a 114aa-115aa region of an NSP4 gene, that is, a coiled-coil region. By researching the rotavirus-encoded small RNA, the mutual regulating relationship between the rotavirus and a host cell is further understood, thereby providing a possible path for finding specific drugs for rotavirus injection and providing a theoretical ground for screening drugs taking RV-VSRNA1755 molecule as a rotavirus therapeutic target in the future.

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