The invention provides a sealing door based on bevel gear driving and screw driving. The sealing door comprises a door plate, a main shaft assembly, four groups of door catch assemblies and supporting assemblies. The main shaft assembly comprises a main shaft which is located in the center of the plane of the door plate and penetrates through the door plate in a way of being vertical to the plane of the door plate, and the main shaft is provided with a first bevel gear; the four groups of door catch assemblies are uniformly distributed around the main shaft and are restrained on the door plate by the respective supporting assemblies, and each of the door catch assemblies is composed of a stepped shaft, a second bevel gear fixedly arranged at one end of the stepped shaft and a nut located fixedly arranged at the other end of the stepped shaft; and each supporting assembly comprises a rolling bearing assembly for supporting the stepped shaft and a sliding bearing assembly for supporting the nut. Each second bevel gear is meshed with the first bevel gear to drive each stepped shaft to rotate and is used for driving each nut to move along the axial direction of the stepped shaft by threaded connection, so that the nuts are wedged into holes of a door frame, the door plate moves along the axial direction of the main shaft, and a sealing strip is pressed; and the sealing door is capable of realizing multipoint locking, large in pressing force and good in sealing effect.