The invention discloses a method for prolonging and regulating the shelf life of an eight-treasure delicious duck by utilizing combined flexible sterilization and belongs to the technical field of meat product processing. The method disclosed by the invention comprises the following steps: adding a nano preservative containing clove/cinnamon/onion composite extract in the stuffing making process of the eight-treasure delicious duck; cooking, performing vacuum packaging on the eight-treasure delicious duck by using a cooking bag, heating and sterilizing the packaged eight-treasure delicious duck in a radio-frequency working chamber; performing short-term high-temperature high-pressure sterilization, and rapidly cooling. According to the method, the problem that the product quality is damaged in the traditional high-temperature high-pressure sterilization method is solved, and the quality preservation complexity of the eight-treasure delicious duck due to the two parts of the duck, namely a duck body and the stuffing, is avoided. After flexible sterilization is performed, the quality preservation rates of color, aroma and shape of the duck body and the stuffing of the eight-treasure delicious duck respectively reach 90% and 88%, commercial sterilization is realized under the condition that any artificial preservative is not added, high-quality shelf life of the product is obviously prolonged, the shelf life at room temperature (25-35 DEG C) in summer can reach 60 days, and the shelf life at low temperature (4 DEG C) can reach 180 days.