The invention discloses a laser precision micro-machining, cleaning and sucking device for a light guide plate. The device comprises a pickup unit, a cleaning unit, a transport unit and a machining unit, wherein the pickup unit is used for picking up the light guide plate and then moving the light guide plate to the cleaning unit, or transferring the light guide plate from the cleaning unit to the transport unit; the cleaning unit is used for cleaning the light guide plate; the transport unit is used for transporting the light guide plate to a machining zone of the machining unit; the machining unit is used for machining the light guide plate with laser. The light guide plate is automatically cleaned before machining, so that various residues, oil dirt and the like of the light guide plate are removed, and machining quality and precision are improved. By means of the automatic pickup device, the degree of automation is increased, the machining efficiency is improved, and the cost is reduced. Automated production of scattering netted dot machining of the light guide plate is realized through coordination work of the units.