The invention discloses a wireless variable resistance device. The device comprises a rheostat module, a hand-held control module and a wireless communication module. The rheostat module comprises an adjustable resistor body, a sliding rod, a sliding rod driving motor, a motor driving controller and a resistance value information acquisition unit. The sliding rod is connected with the adjustable resistor body through a sliding block. The operation of the sliding rod driving motor is controlled through the motor driving controller, so as to make the sliding rod drive the sliding block to slide on the adjustable resistor body. The real-time information of the value of resistance is collected through the acquisition unit of the information of the value of resistance and output to the motor driving controller. The hand-held control module comprises a main controller, a control input unit and a resistance value information output unit. According to the control command which is input through the control input unit, the main controller sends the motor control command to the motor driving controller through the wireless communication module and the main controller acquires the real-time information of the value of resistance simultaneously. The wireless variable resistance device has the advantages of convenience in operation, reliable running and being especially suitable for the variable resistance application and demand of some precision instruments.