The invention discloses a method for improving the yield and quality of paris polyphylla through ultrasonic radiation and foliage spray of agentia. The method comprises the steps that (1) salicylic acid, gibberellin and coumarin are weighed, and solution with a certain concentration is prepared by water; (2) rainless days in the period from March to September are selected for spraying agentia, spraying is conducted before sunrise or after sunset 2-3 times a month, each spraying interval is not less than ten days, and plants are stained with the solution evenly; after spraying is completed every time, eight ultrasonic radiation emitters with the transmitting power of 200 watts and the ultrasonic radiation frequency of 10 MHz to 20 MHz are arranged on the ground per mu evenly, and ultrasonic waves are released for 2-5 hours; the rainless days in the period from April to August are selected, monobasic potassium phosphate solution is sprayed 2-3 times a month, and plants are stained with the solution evenly. According to the method for improving the yield and quality of paris polyphylla through ultrasonic radiation, the yield and quality of paris polyphylla are improved roundly, and the effect is very remarkable.