The invention discloses a hangar door body structure with an icing prevention function and a manufacturing process thereof, and relates to the field of ocean engineering equipment and high technology ships, in particular to a multifunctional integrated hangar door body structure design. The main structure of a door body is a lattice metal corrugated sandwich structure and is prepared by an inner side panel, an outer side panel and a corrugated core body through laser welding; and meanwhile, hot air flow holes and flow pipes are designed in the corrugated core body, a partially communicating core body flow space is formed, the outer side panel is heated by controlling hot air or hot steam to flow in the core body flow space, and an icing prevention purpose is achieved. The weight of the door body structure can be reduced by 10%-25% compared with the weight of an existing plate rib structure door body, and the multifunctional characteristics of bearing, explosion prevention, icing prevention and the like are combined at the same time. The disclosed hangar door body structure and the manufacturing process thereof are suitable for all kinds of hangar door bodies and some other large protective structures with anti-explosion and heat preservation requirements.