The invention discloses a preparation method of rhizoma paridis total saponin solid lipid nanoparticles. The preparation method comprises the following steps: adding a formula dosage of soybean phospholipid and surfactant into a proper amount of purified water; stirring in a water bath at constant temperature and dissolving to prepare a water phase; then adding a formula dosage of rhizoma paridis total saponin and glycerin monostearate into a proper amount of absolute ethyl alcohol in sequence; stirring in a water bath at constant temperature and dissolving to prepare an oil phase; slowly adding the oil phase into the medicine-containing water phase; starting a high-shearing dispersion emulsifying machine to obtain a milk white solution; homogenizing the solution through a high-pressure homogenizing machine and diluting with the purified water and enabling the volume to reach a full dosage; filtering with a membrane and treating in a cold water bath to prepare the rhizoma paridis total saponin solid lipid nanoparticles. The preparation method has the advantages that the prepared rhizoma paridis total saponin solid lipid nanoparticles can be applied to other medicines with similar properties and certain theoretical supports are provided for modernization of traditional Chinese medicine preparations. A quality control level of a traditional Chinese medicine preparation process is improved, so that the aim of improving the quality and competitiveness of traditional Chinese medicine preparation products is realized.