The invention provides a ventilation network equivalent simplification method and device and electronic equipment. The method comprises the following steps: acquiring a ventilation network, wherein the ventilation network comprises air ducts and air duct nodes; detecting the wind resistance of the air ducts, extending towards two ends by taking air ducts of which the wind resistance cannot be detected as a center if the air ducts of which the wind resistance cannot be detected are found, and determining a starting node and a terminal node of a smallest range for encircling the air ducts of which the wind resistance cannot be detected; simplifying the air ducts between the starting node and the terminal node according to a wind resistance equivalence principle. By adopting the ventilation network equivalent simplification method and device and the electronic equipment, the problem that a complex ventilation network including a plurality of air inlet nodes and a plurality of air outlet nodes and internally including a plurality of ventilation nodes and air ducts cannot be simplified in the prior art is solved, and the complex ventilation network can be simplified correctly.