The invention relates to a high-accuracy indoor positioning method based on combination of UWB (Ultra-wide Bandwidth) and Wifi (Wireless Fidelity). The method comprises the following steps: A, confirming a target tag and four base stations being not on the same straight line; B, controlling the tag and the base stations to perform repeated communication, and recording local signal receiving and transmitting time; C, calculating distances between the base stations and the tag according to local signal receiving and transmitting time of the tag and local signal receiving and transmitting time of the base stations; and D, determining a tag position and a system time error by a Newton iterative calculation result according to a calculated result. On the premise that the tag and starting clocks of the four base stations are unknown, the transmission time of electromagnetic waves can be measured accurately; and a result error caused by a clock synchronization error is avoided. Wireless data are received and transmitted by the WiFi under the assistance of the UWB, and WiFi wireless transmission measurement time does not conflict with the UWB, so that the system complexity is lowered. Spatial position estimation is performed on a measurement distance through Newton iteration, so that the accuracy of a measurement result is increased.