The invention relates to the technical field of pipeline fixation, in particular to a fixing and adjusting device for an engine pipeline. The fixing and adjusting device for engine pipeline comprises a bracket, a clamp, a sphere, a supporting rod and an adjusting and fixing component The bracket is fixed with a casing, and a spherical hole penetrating through the bracket is formed on the bracket; the sphere is spherical and mounted in the spherical hole; surface of the sphere is matched with the wall of the spherical hole; threaded holes penetrating through the sphere are formed on the sphere. Axis of each threaded hole passes through the centre of the sphere, one end of the supporting rod is a screw, the other end is the head of the supporting rod, the clamp is sleeved with the pipeline, and two joints of the clamp are fixed on the head of the supporting rob by a fastener. The screw penetrates through the sphere and is fixed with the sphere through the threaded holes, a first nut and a second nut are mounted on the screw, wherein the first nut and the second nut are correspondingly arranged at both sides of the sphere to press the sphere. The adjusting and fixing components are detachably arranged on the bracket, and the adjusting and fixing components fix the sphere in the bracket and prevent the sphere from rotating.