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发明公开
CN107001302A 一类水溶性紫杉烷类衍生物及其用途 有权

一类水溶性紫杉烷类衍生物及其用途
摘要：
本发明公开了一类水溶性紫杉烷类衍生物、使用其治疗肿瘤的方法、其作为抗肿瘤药物的用途以及其在制备抗肿瘤药物药物中的用途。所述水溶性紫杉烷类衍生物具有通式(I‑1)、(I‑2)或(I‑3)：其中，R1为H或甲基；R2为H、甲基或乙酰基；R3为苯基或OC(CH3)3；X为H、C1‑6烷基或F；Y为F或者被一个或多个F取代的C1‑6烷基；n为1、2、3、4、5或6；W为NR4R5·A或R4、R5各自独立地为H、任选地被苯基取代的C1‑6烷基、或C3‑6环烷基；m为0、1、2或3；A为药学可接受的酸。
摘要（英）：

Disclosed are water-soluble taxane derivatives, a method for treating tumor using same, use thereof as anti-tumor drugs and use thereof for preparing anti-tumor drugs. The water-soluble taxane derivatives have general formula(I-1), (I-2) or (I-3): wherein R1 is H or methyl; R2 is H, methyl or acetyl; R3 is phenyl or OC(CH3)3; X is H, C1-6 alkyl or F; Y is F or C1-6 alkyl substituted by one or multi-F; n is 1,2,3,4,5 or 6; W is NR4R5.A or (BB); R4, R5 is each independently H, C1-6 alkyl optionally substituted by phenyl, or C3-6 cycloalkyl; m is 0,1,2 or 3; A is pharmaceutically acceptable acid.

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