The invention discloses a method for producing large-grain oxytetracycline hydrochloride. The method comprises the steps of dissolving, activated carbon decolorization treatment, crystallization and drying; and during batch operation, a mother liquor generated in the previous process is added to a filtrate in the crystallization step and the mother liquor generated in the crystallization step is further used in the next process. According to the method for producing the large-grain oxytetracycline hydrochloride, 1-3 times of mother liquor (produced from the previous round) is added to the filtrate before acid-adding salt formation on the basis of not changing the original technological process, so that an oxytetracycline hydrochloride crude drug which is good in mobility and high in bulk density and meets the requirements of customers can be produced while the yield of the oxytetracycline hydrochloride is effectively increased; and the oxytetracycline hydrochloride crude drug has good practicability.