The invention relates to gas-liquid linkage driving device suitable for a main steam isolating valve, particularly relates to a gas-liquid linkage driving device of high temperature, high pressure ultra-large diameter rapid closing (rapid closing within 2-5 s) main steam isolating valve, and belongs to the field of machinery. The gas-liquid linkage driving device suitable for the main steam isolating valve comprises a hydraulic module, an electrical module, an oil tank and electrical parts which are arranged on a valve stand, and the gas-liquid linkage driving device and the valve stand are arranged integrally. According to the gas-liquid linkage driving device suitable for the main steam isolating valve, the gas-liquid linkage driving device and the valve stand are arranged integrally, and a whole modularization design is adopted, the structure is compact, the size is small, and the weight is small.