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发明公开
CN107075536A 生产3‑羟基‑3‑甲基丁酸的方法 有权

生产3‑羟基‑3‑甲基丁酸的方法
摘要：
本发明描述了一种将3‑甲基巴豆酰基‑CoA转化为3‑羟基‑3‑甲基丁酸的方法，该方法包括以下步骤：(a)将3‑甲基巴豆酰基‑CoA酶促转化为3‑羟基‑3‑甲基丁酰基‑CoA；和(b)进一步将由此产生的3‑羟基‑3‑甲基丁酰基‑CoA酶促转化为3‑羟基‑3‑甲基丁酸；其中，根据步骤(b)的3‑羟基‑3‑甲基丁酰基‑CoA到3‑羟基‑3‑甲基丁酸的酶促转化，通过首先将3‑羟基‑3‑甲基丁酰基‑CoA转化为3‑羟基‑3‑甲基丁酰基‑磷酸、然后将由此生产的3‑羟基‑3‑甲基丁酰基磷酸转化为3‑羟基‑3‑甲基丁酸来实现。
摘要（英）：

Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3- methylbutyric acid comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid.

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