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发明公开
CN107189023A 一种核壳式磁性复合微球及其制备方法和应用 无效 - 撤回

一种核壳式磁性复合微球及其制备方法和应用
摘要：
本发明涉及一种核壳式磁性复合微球及其制备方法和应用，属于天然产物有效成分的分离纯化技术领域；本发明首先制备磁性温敏聚合物Fe3O4@P(GMA‑co‑NIPAM)，将该聚合物分散于亚氨基二乙酸和氢氧化钠的混合水溶液中，剧烈搅拌反应；磁分离后用乙醇和水洗涤；真空干燥至恒重后将产物分散于NiCl2溶液中，室温搅拌后磁分离产物，用去离子水洗涤后真空干燥至恒重得到核壳式磁性复合微球；本发明中制备的磁性微球Fe3O4@P(GMA‑co‑NIPAM)/IDA/Ni2+粒径大约为200 nm，比表面积大，对菠萝蛋白酶的吸附量高达117 mg/g。
摘要（英）：

The invention relates to a core-shell magnetic composite micro-sphere, a preparation method thereof and an application, and belongs to the technical field of separation and purification of effective components of natural products. Firstly, magnetic temperature-sensitive polymer Fe3O4@P(GMA-co-NIPAM) is prepared and dispersed in iminodiacetic acid and sodium hydroxide mixed water solution, and violent stirring reaction is performed. Secondly, products are washed by ethanol and water after magnetic separation. Thirdly, the products are dried in vacuum to reach constant weight and then dispersed in NiCl2 solution, the products are magnetically separated after room-temperature stirring, and the products are washed by deionized water and then dried in vacuum to reach constant weight to obtain the core-shell magnetic composite micro-sphere. The particle size of the prepared magnetic micro-sphere Fe3O4@P(GMA-co-NIPAM)/IDA/Ni<2+> is approximately 200 nanometers, the magnetic micro-sphere is large in specific surface area, and bromelain adsorption quantity reaches up to 117mg/g.

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