The invention discloses a main cable layered anti-sliding structure for main saddles of a suspension bridge, the main cable layered anti-sliding structure is arranged on the main saddles of the suspension bridge and provides additional anti-sliding friction function for main cables. The main cable layered anti-sliding structure comprises friction clamping plates and sliding-resistant devices, the multiple friction clamping plates are arranged inside a main saddle trough, the upper and lower surfaces of the friction clamping plates are curved surfaces capable of being in close contact with cable strands, and a main cable is divided into an upper layer cable strand (2) and a lower layer cable strand (3). The two sliding-resistant devices are symmetrically arranged on both ends of the upper part of a main saddle, and clamp the upper layer cable strand through fastening bolts (9) and prevent the upper layer cable strand from sliding in a longitudinal direction. The main cable layered anti-sliding structure can improve the level of anti-sliding of the lower layer cable strand, and prevents the upper layer cable strand from the risk of first sliding due to poor anti-sliding ability, has the advantages of being clear in fortification goal, simple in stress relation, good in operation capability and the like, and is particularly suitable for multi-tower suspension bridge structures.