The invention provides a roller shutter driving mechanism of an outward-opening automobile panoramic skylight. The outward-opening automobile panoramic skylight comprises a skylight fixed supporting beam, a roller shutter and the roller shutter driving mechanism, the roller shutter driving mechanism is used for driving the roller shutter to open and close on the skylight fixed supporting beam, the roller shutter driving mechanism is composed of a roller shutter driving motor mechanism and a roller shutter motor linkage mechanism, the skylight fixed supporting beam is a U-shaped fixed seat fixedly mounted on a roof skylight opening, the driving motor mechanism of the roller shutter driving mechanism is arranged on the upper end face of an arch-shaped portion of the U-shaped fixed seat, and two ends of a free end of the roller shutter are connected with the roller shutter driving mechanism. The roller shutter driving mechanism is simpler in structure, fewer in parts and easier to combine and mount; a driving motor is mounted at the front end of a front beam of the skylight, so that mounting difficulty is lowered, lines are made more simply, two wires are omitted, and effective space in an automobile is saved; the roller shutter driving mechanism can realize quick loading and is simple in process and higher in efficiency generally.