The invention provides a modification method of high-dispersity nano white carbon black for rubber filler. According to the method, nano white carbon black is modified with aliphatic diisocyanate, then acrylamide is added for an end capping reaction, conjugate diene monomers are pre-emulsified and subjected to in-situ polymerization with unsaturated bonds in acrylamide, so that a blocking layer with high joint strength and adopting a high-dispersity structure is formed on the surfaces of nano white carbon black particles, and the nano white carbon black particles can be separated under a high temperature or high shear action. The method not only solves the problem that nano white carbon black is prone to agglomeration, but also solves the problem that nano white carbon black is agglomerated again due to processing and mixing processes, nano white carbon black is endowed with super dispersity, and the nano white carbon black particles can be dispersed into a rubber system uniformly. The modification method has the advantages that the operation method is simple, the modification cost is low, environmental pollution is small, the method is suitable for industrial production, and the like.