The invention provides a compound shown as a formula (I) or pharmaceutically acceptable salts, solvates, esters, acids, metabolites or pre-drugs thereof. The compound provided by the invention is independently administered in combination with at least one type of additional therapeutic agent to be used for preventing or treating diseases, obstacles or symptoms which are regulated or influenced by the activity of tyrosine kinase C-KIT or diseases, obstacles or symptoms which are related to the activity of tyrosine kinase C-KIT, especially cancers and other cell proliferative diseases. (The formula (I) is shown in the description.).