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发明授权
CN107286087B 一种2-氰基-3-氯-5-三氟甲基吡啶的合成方法 有权

一种2-氰基-3-氯-5-三氟甲基吡啶的合成方法
摘要：
本发明公开了一种2‑氰基‑3‑氯‑5‑三氟甲基吡啶的合成方法，属于有机合成技术领域。所述的方法步骤为：(1)以2,3‑二氯‑5‑三氟甲基吡啶为原料，在溶剂体系内加入催化剂，经氟化合成2‑氟‑3‑氯‑5‑三氟甲基吡啶，(2)将步骤1所的2‑氟‑3‑氯‑5‑三氟甲基吡加入氰化试剂氰化后，经水洗，蒸馏后，得2‑氰基‑3‑氯‑5‑三氟甲基吡啶。产品纯度可达到99.5％，收率可达到90％，过程反应条件温和，易于操作，适合规模化生产。
摘要（英）：

The invention discloses a synthesis method of 2-cyano-3-chloro-5-trifluoromethyl pyridine, belonging to the technical field of organic synthesis. The method comprises the following steps: (1) adding a catalyst into a solvent system, and carrying out fluorination on 2,3-dichloro-5-trifluoromethyl pyridine serving as raw material to synthesize 2-fluoro-3-chloro-5-trifluoromethyl pyridine; (2) adding a cyaniding agent into the 2-fluoro-3-chloro-5-trifluoromethyl pyridine obtained in the step 1 for cyaniding, then washing the product with water, and distilling to obtain the 2-cyano-3-chloro-5-trifluoromethyl pyridine. The purity of the product reaches up to 99.5%, and the product yield is 90%; the method is mild in process reaction conditions, easy to operate and suitable for large-scale production.

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