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发明公开
CN107325034A 一种制备罗匹尼罗二聚物的方法 无效 - 驳回

一种制备罗匹尼罗二聚物的方法
摘要：
本发明提供了一种3,3’-亚甲基罗匹尼罗二聚物的制备方法，包括以下步骤：(a)将罗匹尼罗游离碱或罗匹尼罗与酸形成的盐加入反应溶剂中，接着加入有机碱或无机碱，再加入醛溶液，所述醛选自：甲醛，二聚甲醛，三聚甲醛或多聚甲醛；(b)加热升温至30～100℃反应0.5～36小时；(c)接着分离获得目标产物3,3’-亚甲基罗匹尼罗二聚物。本发明所提供的罗匹尼罗杂质制备方法收率操作简单，产品收率高、纯度好并且成本低。
摘要（英）：

The invention provides a method for preparing 3,3'-ropinirole methylene dimer. The method comprises steps as follows: (a) salt formed by ropinirole free alkali or ropinirole and acid is added to a reaction solvent, organic alkali or inorganic alkali is added, and an aldehyde solution is added, wherein aldehyde is selected from formaldehyde, dimeric formaldehyde, trimeric formaldehyde or paraformaldehyde; (b) the mixture is heated to 30-100 DEG C to react for 0.5-36 hours; (c) a target product 3,3'-ropinirole methylene dimer is obtained after separation. The provided preparation method of the ropinirole impurity is simple to operate, high in product yield, good in purity and low in cost.

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