The invention relates to an anti-interference coaxial loading mechanism. The anti-interference coaxial loading mechanism comprises a foundation (1), supports (2), an actuator (3), a sensor (4), a U-shaped force application rod (6) with a handle and a self-locking nut (9), wherein the supports (2) are three in a line and are mounted on the foundation (1), the actuator (3) is mounted at two adjacent supports (2), one end is hinged on the outer support, the other end is arranged on the inner support (2), the sensor (4) and the actuator (3) are in fastening connection, and the U-shaped force application rod (6) with the handle is mounted on the sensor (4) and is fastened with the sensor (4) through the self-locking nut (9). The anti-interference coaxial loading mechanism is advantaged in that through the ingeniously-designed U-shaped force application rod (6) with the handle, force gap bridge transmission is realized, precise coaxial reciprocating loading of a test member is realized, through mother-son rod screw design, force application stability is effectively guaranteed, the anti-interference coaxial loading mechanism is simple and reliable in design, and the effect is good.