The invention discloses a synthesis process of an antibacterial debonding agent, the antibacterial debonding agent and an application. The synthesis process comprises the steps of firstly carrying out substitution reaction on triethanolamine and thionyl chloride as raw materials in an organic solvent; and then adding long-chain alkyl tertiary amine to the product and carrying out quaternary ammonium salt reaction to synthesize the antibacterial debonding agent. The antibacterial debonding agent is applied to a fluff fiber to prepare the antibacterial fluff fiber and can be applied to antibacterial household paper and senior household paper; and the obtained product is good in antibacterial effect and has relatively good softening property.