The invention discloses a synthesis method for conveniently and industrially producing sulbenicillin sodium. The synthesis method comprises the following steps: (1) carrying out sulfonation reaction; (2) carrying out alkalization reaction; (3) carrying out ion exchange; (4) carrying out chlorination and acylation reaction; (5) extracting sulfophenyl acetylchloride; (6) preparing D-(-)-alpha-sulbenicillin; (7) preparing D-(-)-alpha-sulbenicillin sodium. According to the synthesis method for conveniently and industrially producing the sulbenicillin sodium, disclosed by the invention, a reasonable synthesis route is designed so that complicated operation of disodium sulfophenyl acetate is simplified and the yield is improved; a synthesis process is used for directly preparing optically pure D-(-)-alpha-sulbenicillin, so that the cost is saved, industrial production is more easily realized and the market prospect is wide.