The invention discloses a weariness-resistant solid beverage and a preparation method thereof, and belongs to the field of weariness-resistant beverages. The solid beverage comprises the following components in parts by mass: 15-20 parts of Acai berries, 10-12 parts of taurine, 6-8 parts of whey protein powder, 6-8 parts of soybean protein powder, 8-12 parts of myo-inositol, 8-12 parts of trepang, 6-9 parts of edible glucose, 6-9 parts of vitamin C, 4-6 parts of citric acid, 6-9 parts of potassium chloride, 3-6 parts of resistance dextrin, 2-3 parts of sodium citrate and 0.3-0.5 part of edible essence. The preparation method comprises the following steps of performing extraction, performing drying, performing mixing, performing granulation, performing granule trimming and the like. According to the weariness-resistant solid beverage disclosed by the invention, all the components mutually cooperate to have synergistic effects, the outstanding efficacy of resisting weariness is achieved through multiple ways of complementing energy, reducing lactic acid, improving the stability of internal environment of bodies, alleviating physical weariness or mental weariness, removing free radicals and the like, the weariness-resistant solid beverage can adapt to the weariness caused by various reasons, and can also improve the immunity of the organisms.