The invention provides methyl N-tetradecyl acetimidate and a synthesis method thereof. The synthesis method comprises the following steps: dissolving acetal and tetradecylamine into methanol, wherein the molar ratio of acetal to tetradecylamine is (1: 1) to (1.5: 1) and the weight of methanol is 50-99% of the total weight; heating to the specified temperature, and reacting for 0.1-12 h under the atmospheric pressure; and reducing the pressure to 0.01-0.08 MPa, reacting for 0.25-12 h at 20-120 DEG C, and stopping the reaction to obtain methyl N-tetradecyl acetimidate. The invention further provides methyl N-tetradecyl acetimidate synthesized by the synthesis method. The yield of N-substituted imidoester synthesized by the synthesis method of methyl N-tetradecyl acetimidate can reach 72% or above, operation is simple, and the volatile product is easy to recycle and environment-friendly.