The invention discloses a comprehensive utilization system for water resource for white spirit brewing and a method and relates to the technical field of white spirit brewing. The comprehensive utilization system for water resource for white spirit brewing disclosed by the invention comprises a central control system and a soft water system, a distillation system, a cooling system and a hot water system which are respectively connected with the central control system, wherein the central control system is used for performing functional control on the soft water system, the distillation system, the cooling system and the hot water system; the soft water system, the distillation system, the hot water system and the cooling system are connected with each other in turn; the cooling system is connected with the distillation system. The system is intelligently controlled by the central control system and is high in degree of automation; the inflowing water of the system is treated by the soft water system and then is reused, so that the water is saved, the equipment maintenance cost is lowered, the pollution discharge is reduced and the energy consumption is reduced; the comprehensive utilization method for water resource for white spirit brewing and the system disclosed by the invention can realize automatic technology; the distillation cooling inflowing water adopts the mode of high-low level inflowing; the wine-receiving temperature is stably controlled and the quality of the white spirit is guaranteed.