The invention discloses a method for directly constructing a high optical activity allene compound combing axial chirality and central chirality. Under effects of a palladium catalyst, a chiral diphosphine ligand and alkali, 2,3-allene function group compounds shown in a formula (1) and a nucleophilic reagent in a formula (2) are reacted in an organic solvent, and the high optical activity allene compound combing axial chirality and central chirality can be directly constructed by one step. The method has the advantages of simple operation, easy acquisition of raw material and the reagent, mild reaction condition, wide substrate universality, and good function group compatibility, and the stereoselective performance of the product is excellent (greater than 99:1 d.r., 95-greater than 99% ee). The high optical activity allene compound can be taken as an important intermediate for constructing the compounds such as monofluoro methylation allene, gamma-allene acid ester, gamma-allene acid, gamma-allenol, and gamma-butanolide containing several chiral centers.