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发明公开
CN107496421A EP4受体拮抗剂在软骨疾病的治疗中的用途 无效 - 驳回

EP4受体拮抗剂在软骨疾病的治疗中的用途
摘要：
本发明涉及EP4受体拮抗剂在软骨疾病的治疗中的用途。更具体而言，本发明涉及在软骨疾病的治疗中有用的具有EP4受体拮抗活性的化合物或其药学上可接受的盐。本发明还涉及在软骨疾病的治疗中有用的具有EP4受体拮抗活性的通式(I)、(II)、(III)、(IV)、(Va)或(Vb)的化合物或其药学上可接受的盐；以及用于治疗软骨疾病的药物组合物，其包含治疗有效量的通式(I)、(II)、(III)、(IV)、(Va)或(Vb)的化合物或其药学上可接受的盐。进一步地，本发明涉及用于治疗包括哺乳类受治者在内的动物受治者中的软骨疾病的方法，包括将通式(I)、(II)、(III)、(IV)、(Va)或(Vb)的化合物或其药学上可接受的盐给药于所述受治者。
摘要（英）：

This invention relates to a compound with EP4 antagonistic activity, or a pharmaceutically acceptable salt with EP4 receptor antagonistic activities, which is useful in the treatment of cartilage disease. This invention also relates to a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof with EP4 receptor antagonistic activities, which is useful in the treatment of cartilage disease. This invention also relates to a pharmaceutical composition for the treatment of cartilage disease which comprises a therapeutically effective amount of a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof. Further this invention relates to a method for the treatment of cartilage disease in an animal subject including a mammalian subject, which comprises administering to the animal subject including a mammalian subject a compound of the formula (I), (II), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof.

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