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发明公开
CN107501061A 一种2-甲氧基-6,7,8,9-四氢苯并环庚烷-5-酮的制备方法 无效 - 驳回

一种2-甲氧基-6,7,8,9-四氢苯并环庚烷-5-酮的制备方法
摘要：
本发明公开了一种合成2-甲氧基-6,7,8,9-四氢苯并环庚烷-5-酮的方法，其步骤为：间卤苯甲醚与戊二酸酐反应制备5-(3-甲氧基苯基)-5-氧代戊酸，还原5-(3-甲氧基苯基)-5-氧代戊酸制备5-(3-甲氧基苯基)戊酸；5-(3-甲氧基苯基)戊酸通过分子内傅克酰基化反应得到2-甲氧基-6,7,8,9-四氢苯并环庚烷-5-酮。本发明公开的方法合成步骤短、成本低、总收率高，可用于工业化生产。
摘要（英）：

The invention discloses a method of synthesizing 2-methoxy-6,7,8,9-tetrahydrobenzocycloheptane-5-one. The method includes the steps of: performing a reaction to m-halogen anisole and glutaric anhydride to prepare 5-(3-methoxyphenyl)-5-oxopentanoic acid; reducing the 5-(3-methoxyphenyl)-5-oxopentanoic acid to prepare 5-(3-methoxyphenyl) pentanoic acid; and performing intermolecular Friedel-Crafts acylation reaction to the 5-(3-methoxyphenyl) pentanoic acid to obtain the 2-methoxy-6,7,8,9-tetrahydrobenzocycloheptane-5-one. The method has fewer steps, low cost and high total yield, and is suitable for industrial production.

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