The invention relates to the technical field of medicines, in particular discloses an effervescent tablet containing alpha-ketoacid and a preparation method of the effervescent tablet. The effervescent tablet containing the alpha-ketoacid is prepared from the following ingredients in parts by weight: 60-100 parts of alpha-ketoacid, 230-410 parts of alpha-ketoacid salt, 20-100 parts of trehalose, 10-60 parts of L-glutamine, 1-10 parts of amino magnesium acetate, 1-10 parts of carnosine zinc, 1-10 parts of lysine, 1-10 parts of arginine and 5-60 parts of a flavor agent. According to the effervescent tablet containing the alpha-ketoacid, which is provided by the invention, specific alpha-ketoacid, specific alpha-ketoacid salt and specific amino acid serve as main ingredients, various ingredients are compatible, the replenishment of energy and amino acid is effectively improved, the body fluid equilibrium is promoted, so that the effervescent tablet containing the alpha-ketoacid can be used as a health care product to relieve the symptoms of sub-healthy crowds such as psoas ache, weakness and dizziness, meanwhile, the trehalose and the flavor agent are added in the effervescent tabletcontaining the alpha-ketoacid, the mouthfeel of the effervescent tablet is improved, a user can rapidly get rid of a sub-healthy state, so that the effervescent tablet is conducive to recovering somatic functions.