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发明授权
CN107574581B 一种抗菌性聚(ε-己内酯)/模拟抗菌肽电纺纤维膜及其制备方法 失效 - 权利终止

一种抗菌性聚(ε-己内酯)/模拟抗菌肽电纺纤维膜及其制备方法
摘要：
本发明涉及一种抗菌性聚(ε‑己内酯)/模拟抗菌肽电纺纤维膜及其制备方法，属于生物高分子材料领域。本发明的步骤：首先将聚(ε‑己内酯)与模拟抗菌肽按质量比24:1～3:1混合，溶于三氟乙醇中，搅拌36～48h，配置混合均匀的质量浓度为100～160mg/mL的电纺溶液。然后通过溶液静电纺丝的方法制备出聚(ε‑己内酯)/模拟抗菌肽电纺纤维膜。该方法的优点是过程简单、易于操作、成本较低。本发明的电纺纤维膜材料亲疏水性可调、具有良好的细胞相容性，同时在表面上存在一定量的模拟抗菌肽，对革兰氏阴性菌和革兰氏阳性菌均表现出较为明显的抗菌活性，适用于生物医用领域。
摘要（英）：

The invention relates to an antibacterial poly(epsilon-caprolactone)/simulated antibacterial peptide electrospun fibrous membrane and a preparation method thereof, and belongs to the field of biological high polymer materials. The method comprises the steps that firstly, poly(epsilon-caprolactone) and simulated antibacterial peptide are mixed on the basis of the mass ratio being 24:1-3:1 and dissolved into trifluoroethanol to be stirred for 36-48 h, and an evenly-mixed elecrospun solution with the mass concentration being 100-160 mg/mL is prepared; then, the antibacterial poly(epsilon-caprolactone)/simulated antibacterial peptide electrospun fibrous membrane is prepared through the solution electrostatic spinning method. The method has the advantages that the process is simple, operation is easy and the cost is low. The electrospun fibrous membrane is adjustable in hydrophilicity and hydrophobicity, has the good cytocompatibility, meanwhile has the certain amount of simulated antibacterial peptide on the surface, has the obvious antibacterial activity on gram negative bacteria and gram positive bacteria, and is applicable to the field of biomedicine.

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