The invention discloses a full three-dimensional simulation method for an acidification flow experiment. According to the method, a differential method is utilized to discrete a fluid seepage continuity equation and an acid-liquid mass diffusion reaction equation, and an H+ local equilibrium equation, a porosity change equation, a permeability change equation and a pore throat radius change equation are established at the same time; initial conditions and boundary conditions are substituted into the simulation equations; a simulation program is compiled by utilizing the equations, the initialconditions and the boundary conditions; 6, reservoir cores are scanned to obtain three-dimensional spatial distribution parameters of porosity; a three-dimensional spatial distribution model of the porosity is established, and the compiled program is utilized to achieve full three-dimensional numerical simulation of the acidification flow experiment on the basis of the established three-dimensional spatial distribution model of the porosity. According to the method, full three-dimensional numerical calculation is adopted, the calculation precision is effectively improved, and meanwhile the influence laws of each parameter on the development of wormholes are conveniently, quickly and accurately studied.