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发明授权
CN107635993B 取代的三环杂环化合物 有权

取代的三环杂环化合物
摘要：
本申请公开了式(I)的化合物或其盐，其中：X为N；W为：(i)‑(CR3R3)1‑4‑；(ii)‑(CR3R3)x‑Y‑(CR3R3)y‑；或(iii)‑Y‑(CR3R3)2‑Y‑；并且Y、R1、R2、R3、R5、R6、R8、x和y在本文中定义。本申请还公开了使用所述化合物作为TNFα调节剂的方法，以及包含所述化合物的药物组合物。这些化合物用于治疗炎性疾病和自身免疫性疾病。
摘要（英）：

Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

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