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发明公开
CN107739368A N-取代-5-（（4-取代嘧啶-2-基）氨基）吲哚类衍生物及其制备方法和用途 失效 - 权利终止

N-取代-5-（（4-取代嘧啶-2-基）氨基）吲哚类衍生物及其制备方法和用途
摘要：
N-取代-5-((4-取代嘧啶-2-基)氨基)吲哚类衍生物及其制备方法和用途，涉及恶性肿瘤药物。N-取代-5-((4-取代嘧啶-2-基)氨基)吲哚类衍生物的结构如式I所示。一类N-取代-5-((4-取代嘧啶-2-基)氨基)吲哚类衍生物在制备抗肿瘤药物及抗HIV药物的应用一类新颖的同时且具有抑制CDK9和HDACs信号通路活性的衍生物，通过抑制CDK9和HDACs相关信号通路活性，阻断肿瘤细胞增殖，诱导细胞凋亡，从而可以用于人和动物的多种疾病如恶性肿瘤的治疗和预防。
摘要（英）：

The invention discloses an N-substituted-5-((4-substituted pyrimidine-2-yl)amino)indole derivative as well as a preparation method and a purpose thereof, and relates to malignant tumor drugs. A structure of the N-substituted-5-((4-substituted pyrimidine-2-yl)amino)indole derivative is shown as a formula I. For application of the N-substituted-5-((4-substituted pyrimidine-2-yl)amino)indole derivative in preparing an antitumor drug and an anti-HIV drug, a novel derivative which inhibits the signal pathway activities of CDK9 and HDACs is applied to blocking tumor cell proliferation and inducing cells apoptosis by inhibiting relative signal pathway activities of the CDK9 and the HDACs, and thus can be used for treating and preventing various diseases such as malignant tumors of humans and animals.

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