The invention provides a benzoxazole-2-ethyl oxime derivate. The benzoxazole-2-ethyl oxime derivate is as shown in a formula (I) or a formula (II), wherein X1 and X2 are independently selected from NHor O; R1 and R3 are independently selected from H, F, Br or C1; R2 is selected from C1-C10 alkyl, substituted C1-C10 alkyl, phenyl or substituted phenyl; the substituted group of the substituted C1-C10 alkyl is selected from phenyl or halogen. Compared with the prior art, the benzoxazole-2-ethyl oxime derivate as shown in the formula (I) or the formula (II) is capable of obviously reducing anklejoint swelling degree and serum uric acid level of a rat with acute gouty arthritis, and is high in NLRP3 and TLR4 dual inhibition activity; the effect of the benzoxazole-2-ethyl oxime derivate is obviously prior to that of positive control dexamethasone; the benzoxazole-2-ethyl oxime derivate is applicable to preparation of drugs for treating hyperuricemia or acute gouty arthritis, and is small in side effect, and high in safety. (The formula is shown in the description).