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发明公开
CN107773554A 一种伊维菌素缓释微囊及其制备方法和应用 无效 - 驳回

一种伊维菌素缓释微囊及其制备方法和应用
摘要：
本发明公开了一种伊维菌素缓释微囊及其制备方法和应用。所述伊维菌素缓释微囊包括以下质量百分比的各组分：伊维菌素原料0.1～1％，水溶性载体20～60%，肠溶性包裹材料30～70%；其中水溶性载体为羟丙基-β-环糊精、甲基-β-环糊精、HPMC、PVP、PEG、泊洛沙姆188、甘露醇、D-α-生育酚PEG1000琥珀酸酯、胆盐/磷脂混合胶团、聚乙二胺树枝状聚合物、磷脂或胆固醇中的一种或几种；肠溶性包裹材料为羟丙基甲基纤维素邻苯二甲酸、丙烯酸树脂Ⅱ号、丙烯酸树脂Ⅲ号、邻苯二甲酸醋酸纤维素、聚乙烯邻苯二醋酸酯或羟丙基甲基纤维素醋酸琥珀酸酯中的一种或几种。本发明伊维菌素缓释微囊在耐酸性方面具有突出的优点，使药物到达肠道才崩解释放，显著提高生物利用度且疗效显著。
摘要（英）：

The invention discloses an ivermectin controlled-release capsule and a preparation method and application thereof. The ivermectin controlled-release capsule comprises, by mass, 0.1-1% of ivermectin raw material, 20-60% of water-soluble carrier and 30-70% of enteric-soluble wrapping material, the water-soluble carrier is one or multiple of hydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin,HPMC, PVP, PEG, poloxamer 188, mannitol, D-alpha-tocopherol PEG 1000 succinate, cholate/phospholipid mixed micelle, polyethylenediamine dendritic polymer, phospholipid or cholesterol, and the enteric-soluble wrapping material is one or multiple of hydroxypropyl methyl cellulose phthalic acid, acrylic resin II, acrylic III, cellulose acetate phthalate, polyethylene diacetate phthalate or hydroxypropyl methyl cellulose acetate succinate. The ivermectin controlled-release capsule has the advantage of outstanding acid resistance, enables drug to reach intestinal tracts to be disintegrated and released, remarkably improves bioavailability and has remarkable treatment effect.

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