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发明公开
CN107793341A 一种维格列汀中间体的制备方法 审中-实审

一种维格列汀中间体的制备方法
摘要：
本发明涉及一种维格列汀中间体的制备方法所述方法包括以下步骤：步骤1，L-脯氨酰胺溶解于加热的有机溶剂中；步骤2，加入氯乙酰氯反应，步骤3，反应结束后，过滤，用步骤1所述的有机溶剂淋洗固体，干燥得到(S)-1-(2-氯乙酰基)-2-吡咯烷甲酰胺盐酸盐。
摘要（英）：

The invention relates to a preparation method of a vildagliptin intermediate. The preparation method comprises the following steps: step 1, dissolving L-prolinamide in a heated organic solvent; step 2, adding chloroacetyl chloride for reaction; and step 3, after the reaction is finished, carrying out filtering, carrying out drip washing on the obtained solid by using the organic solvent in the step 1, and carrying out drying to obtain (S)-1-(2-chloroacetyl)-2-pyrrolidine carboxamide hydrochloride.

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