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发明公开
CN107879939A 一种制备 N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐的方法 无效 - 撤回

一种制备 N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐的方法
摘要：
本发明涉及一种制备N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐的方法。具体地，所述的方法采用化合物(Ⅱ)为起始原料，经过简单的取代和精制成盐便可制得N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐(Ⅰ)。该合成路线具有操作简便，环境友好，收率好，获得的产品的光学纯度高，易于工业化生产等优点。
摘要（英）：

The invention relates to a method of preparing N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(trifluoromethyl) phenyl)-propyl-1-amine hydrochloride. Specifically, the method can prepare N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(trifluoromethyl) phenyl)-propyl-1-amine hydrochloride (I) through simple substitution and refining and salifying by taking a compound (II) as an initial raw material. The synthetic route hasthe advantages of being simple to operate, environment-friendly, good in yield, high in optical purity of obtained products, easy for industrial production and the like. The formula is as shown in thedescription.

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