The embodiment of the invention provides a city integrated pipe gallery monitoring and operation management system and method. The city integrated pipe gallery monitoring and operation management system comprises a pipe gallery level monitoring system, an inter-domain gateway and a city level monitoring center. The pipe gallery level monitoring system acquires the state data of a third-party subsystem and the state data of front-end equipment and transmits the acquired state data to the city level monitoring center through the inter-domain gateway. The city level monitoring center receives thestate data and generates the corresponding processing instruction according to the state data and transmits the processing instruction to the pipe gallery level monitoring system through the inter-domain gateway. The pipe gallery level monitoring system issues the processing instruction to the third-party subsystem and the front-end equipment. All the pipe gallery level monitoring systems are integrated in the city integrated pipe gallery monitoring and operation management system so that monitoring and operation management of the pipe gallery of the whole city can be realized, the operationmanagement level and the safety protection level of the pipe gallery can be effectively enhanced, and the problem of waste of investment caused by the fact that each pipe gallery project has independent investment and construction of the integrated monitoring and operation and maintenance management system can also be solved.