The invention discloses a compound preparation for dispelling the effect of alcohol and a preparation method thereof. The method comprises the following steps of adding kudzu vine roots and clam extract into medicinal and edible fungi in the process of fermenting the medicinal and edible fungi; performing homogenizing and spray-drying after fermentation is finished to prepare the fermented compound preparation. The compound preparation can be further developed into chewable tablets, granules and other product modes. The compound preparation has good taste and high activity, and has an excellent effect for dispelling the effect of alcohol.