The invention provides a preparation method of super-wear-resistant and high-toughness artificial hip joint with biological activity. The preparation method comprises six steps of preparation of a steel mold, preparation of an artificial hip joint germule, formation of a pore, filling of the pore with a PLLA/nHA compound, spraying of a PGA/nHA composite coating layer and surface degradation treatment. A composite material of polyether-ether-ketone and hydroxyapatite whiskers is used as a stent material; the pore is formed in a position corresponding to the stent material, and is filled with the degradable PLLA/nHA active composite material; then the PGA/nHA composite coating layer is sprayed; after the surface degradation treatment is performed, the super-wear-resistant and high-toughnessartificial hip joint with biological activity is obtained. The artificial hip joint prepared through the preparation method is combined with bones via the self-healing effect of bone induced cells onthe bones, and is higher in mechanical property, biological compatibility and bone combination strength than a conventional product.