The invention relates to a region network distribution loss reduction method. The method comprises the following steps: performing region feature extraction, and constructing a region feature database; performing hierarchical clustering on the region features in the region feature database, and establishing line loss rate prediction models for inhomogeneous region features to obtain line loss rateprediction values; performing line loss rate modification on the region with abnormal line loss rate; acquiring an association rule influencing the line loss rate level by adopting the Apriori algorithm according to the obtained line loss rate, and implementing the network distribution loss reduction according to the association rule. Compared with the prior art, the association rule influencingthe line loss rate level is acquired according to the line loss rate prediction model, thereby performing the network distribution loss reduction according to management rule guidance; and meanwhile,the line loss rate computation relates to the line loss rate modification in abnormal region, and the computation result is more accurate.