The invention discloses an annual regional vegetation coverage calculation method. The method comprises steps that accurate radiation calibration, atmospheric correction and geometric registration arecarried out for all remote sensing images of the same annual region, and a remote sensing image result set is acquired, based on the constructed cloud layer index, the shadow index, the background index and the vegetation index, the corresponding special information is extracted; remote sensing images of different time phases are processed through utilizing the de-cloud algorithm and the de-shadow algorithm respectively; spatial synthesis of the single phase vegetation index information is carried out; fusion of the annual multi-phase information is carried out, the spatial distribution map of the annual regional vegetation index information is calculated; and lastly, the spatial distribution map of the annual regional vegetation coverage information is calculated. The method is advantaged in that influence of weather, terrain, phase, vegetation type and environment factors on the vegetation coverage rate is eliminated, an annual regional vegetation coverage calculation problem is solved, accuracy and reliability of regional vegetation coverage calculation are improved, the operation process is simple and flexible, and the method is easy for popularization and application in the regional scale.