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CN107935903A 降血糖药物格列美脲的制备方法 无效 - 撤回

  • 专利标题： 降血糖药物格列美脲的制备方法
  • 专利标题（英）： Preparation method of hypoglycemic drug-glimepiride
  • 申请号： CN201810080482.4
    申请日： 2018-01-27
  • 公开(公告)号： CN107935903A
    公开(公告)日： 2018-04-20
  • 发明人: 董丹丹
  • 申请人： 董丹丹
  • 申请人地址： 江西省赣州市安远县青年路153号
  • 专利权人： 董丹丹
  • 当前专利权人： 董丹丹
  • 当前专利权人地址： 江西省赣州市安远县青年路153号
  • 主分类号： C07D207/38
  • IPC分类号： C07D207/38
降血糖药物格列美脲的制备方法
摘要：
本发明公开了降血糖药物格列美脲的制备方法，所述降血糖药物格列美脲化学名1-[4-[2-(3-乙基-4-甲基-2-氧代-3-吡咯啉-1-甲酰胺基)-乙基]-苯磺酰]-3-(反式-4-甲基环己基)-脲,其化学式为C24H34N4O5S，其结构式为：；本发明制备工艺简洁，合成路线短，收率高，特别是2-(3-乙基-4-甲基-2-氧代-3-吡咯啉-1-甲酰胺基)乙基苯磺酸的收率大大提高，采用的氯磺酸对于磺化效果有很大影响，较于现有技术中使用的磺化剂浓硫酸、发烟硫酸等磺化能力更强，便于进一步生成格列美脲，原料易得，经济环保，产品收率与产品纯度高，有利于工业化。
摘要（英）：

The invention discloses a preparation method of a hypoglycemic drug-glimepiride. The chemical name of the hypoglycemic drug-glimepiride is 1-[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-formamido)-ethyl]-benzenesulfonyl]-3-(trans-4- methyl cyclohexyl)-urea, the chemical formula of the hypoglycemic drug-glimepiride is C24H34N4O5S, and the structural formula of the hypoglycemic drug-glimepiride is described in the description. The preparation method is simple in process, short in synthetic route and high in yield, and especially increases the yield of 2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-formamido)ethyl benzene sulfonic acid greatly; the application of chlorosulfonic acid has great influence on a sulfonation effect; compared with sulfonating agents such as concentrated sulfuric acid and fuming sulfuric acid which are used in the prior art, the chlorosulfonic acid has higher sulfonating capacity, so that the production of the glimepiride is further facilitated; the preparation method iseasy in obtaining of raw materials, economical and environment-friendly, high in product yield and product purity, and beneficial to industrialization.

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